Morin & Its Derivatives

Morin - Bioflavonoid Properties, Uses and Benefits

Learn about Morin, a bioflavonoid with anti-inflammatory, antioxidant, and anticancer properties. Discover its uses in textile dyeing, analytical chemistry, and more. Find out why Morin is used to treat various diseases.

Morin - Bioflavonoid Properties, Uses and Benefits

Discover its uses in textile dyeing, analytical chemistry and more...

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Product Description and Applications

Morin (M3735) and Morin hydrate (2′,3,4′,5,7-Pentahydroxyflavone, CAS 480-16-0 resp. CAS 654055-01-3) is a bioflavonoid mainly obtained from fruits, stem, and leaves of Moraceae family members’ plants.1 The yellow-beige chemical compound can be isolated from Maclura pomifera (Osage orange), Maclura tinctoria (old fustic), and from leaves of Psidium guajava (common guava).2, 6 Other names are: Aurantica, Calico Yellow, Toxylon pomiferum and Bois d’arc.

Morin has been described to have a wide range of pharmacological properties, including anti-inflammatory, antioxidant, free radical scavenging in various diseases like cancer, acute lung injury, liver injury, neuroinflammatory disorders, nephrotoxicity, diabetes, gastritis, mastitis, and myocardial infarction. 1

Flavonoids such as Morin are the most significant natural antioxidants with intense anti-cancer action under both in-vivo and in-vitro conditions. 3, 4

Since the beginning of industrialization, Morin has been used as the best yellow dye for cotton, wool, and silk. For this purpose, the goods to be dyed were first pretreated with metal salts. Various colors could be achieved by reacting Morin with the metal ions. Morin produces olive-green colors with iron salts, brown-yellow with copper salts, and yellow with lead and tin salts.5

In analytical chemistry Morin (M3735) is used for fluorometric detection experiments for various metal ions like aluminum, beryllium, gallium, indium, scandium, titanium and tin.5

From US Patent 5492615 and DE Patent 1009380 also the use of flavonoles for the electrolytic deposition of tin layers is known.

Benefits / USP

  • Despite its large potential and use in industrial scale, Morin is still only available after extraction from a very slow growing tropical tree (mainly Maclura tinctoria or Dyer’s Mulberry), to be found only in the neotropics, making Morin expensive and ecologically unsustainable. European Union will limit the import of products from unsutainable sources end of 2026. EU rules to guarantee that the products EU citizens consume do not contribute to deforestation or forest degradation worldwide.8
  • The Morin quality, currently used on the market on a kilogram scale has so far been extracted from tropical timber and is offered in a strongly varying purity between 65% and 85% (m/m).
  • ORSAtec is addressing the problem of erratic purity thanks to its patented chemical synthesis 7 of Morin (US-11312696-B2, EP4169911A1).
  • Thanks to the HPLC controlled purity and high concentration (≥ 95% (m/m)) of ORSAtec´s Morin product it works much better and more predictably than the natural compound.

Packaging and Pricing

ORSAtec´s Morin ((M3735) , CAS 480-16-0, ≥ 95.0 % purity) is available in different pack sizes:

Amount Price
1 gram 35,00 €
5 gram 50,00 €
25 gram 225,00 €
1000 gram 3.850,00 €

For bulk volumes please request your personal quote. HS codes for Morin and Morin extracts: 2932 99 00, 3203 0010, 3204 1399.

Safety data sheet, Certificate of Analysis and NMR

SDS download

Safety Data Sheet

CoA download

Certificate of Analysis

1H & 13C NMR download

NMR Spectra

Citations:

  1. Shahid Ali Rajput, Xiu-qi Wang, Hui-Chao Yan, Morin hydrate: A comprehensive review on novel natural dietary bioactive compound with versatile biological and pharmacological potential, Biomedicine & Pharmacotherapy, Vol. 138, 2021, 111511.
  2. Rattanachaikunsopon, Pongsak; Phumkhachorn, Parichat (2007). “Bacteriostatic effect of flavonoids isolated from leaves of Psidium guajava on fish pathogens”. Fitoterapia. 78 (6): 434–436. doi:10.1016/j.fitote.2007.03.015. PMID 17553634.
  3. V. Sivaramakrishnan, P.N.M. Shilpa, V.R.P. Kumar, S.N. Devaraj: Attenuation of N-nitrosodiethylamine-induced hepatocellular carcinogenesis by a novel flavonol-Morin, Chem. Biol. Interact., 171 (1) (2008), pp. 79-88.
  4. Q. Zhang, F. Zhang, K. Thakur, J. Wang, H. Wang, F. Hu, J.-G. Zhang, Z.-J. Wie, Molecular mechanism of anti-cancerous potential of Morin extracted from mulberry in Hela cells, Food Chem. Toxicol., 112 (2018), pp. 466-475.
  5. https://de.wikipedia.org/wiki/Morin_(Farbstoff)
  6. Shekhar Kumar, Akanksha Raghuvanshi, Aman Kumar, Vikramdeep Monga, Morin: A Comprehensive Review of Its Sources, Nutraceutical Prospects, Chemistry, and Pharma-cological Insights, Phytotherapy Research, 2026; 0:1–41.
  7. Grigor Gurzadyan, Steffen Mende, Alexander Schmid, Thomas Lindel, Multigram, Chromatography-Free Synthesis of the Flavonol Morin, Org. Process Res. Dev. 2023, 27, 890−898.
  8. https://environment.ec.europa.eu/topics/forests/deforestation/regulation-deforestation-free-products_en
FAQ

Frequently Asked Questions (FAQ) About Morin

Morin, also known as Morin (M3735) or Morin Hydrate (2′,3,4′,5,7-Pentahydroxyflavone x H2O), is a naturally occurring flavonoid compound found in several plant species. It is widely recognized for its use in research, analytical applications, and natural product studies. Industrial applications are in: dye works, cosmetics and personal care products, nutrition additives, additives for plastic applications and additives for the electroplating industry (PCB).

The primary CAS numbers related to Morin are:

  • CAS 480-16-0 – Morin
  • CAS 654055-01-3 – Morin Hydrate

These CAS numbers are commonly used for product identification, procurement, and scientific references.

EINECS, EC: 207-542-9 & 684-856-6

PUB CHEM CID: 5281670 & 16219651

Depending on the product form and application, Morin may be classified under the following HS codes:

  • 2932 99 00
  • 3203 0010
  • 3204 1399

HS codes are important for international trade, customs clearance, and import/export documentation.

  • Morin is naturally found in several plant species, including:• Maclura pomifera (Osage orange)
  • Maclura tinctoria (Old Fustic)
  • Psidium guajava (Common Guava) leaves

These plants are recognized as significant natural sources of Morin.

IUPAC Name

2-(2,4-dihydroxyphenyl)-3,5,7-trihydroxychromen-4-one

InChI

InChI=1S/C15H10O7/c16-6-1-2-8(9(18)3-6)15-14(21)13(20)12-10(19)4-7(17)5-11(12)22-15/h1-5,16-19,21H

InChIKey

YXOLAZRVSSWPPT-UHFFFAOYSA-N

SMILES

C1=CC(=C(C=C1O)O)C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)O

partition coefficient (P) XLogP3-AA

1.5

pKa est.

10.44 (weak base)

Molecular weight

302.23 g/mol

Vapor pressure est.

0 hPa @ 20°C
0 hPa @ 25°C

Evaporation rate

Ultra slow

Boiling point est.

970°C

Melting point expt.

303 – 304 °C

Flash point

261.26 ˚C est.

Solubility @25˚C

Solvent Solubility (g/L)
ethanol 13.52
methanol 12.2
isopropanol 11.98
water 0.0
ethyl acetate 8.4
n-propanol 15.15
acetone 2.92
n-butanol 15.49
acetonitrile 1.7
DMF 79.71
toluene 0.1
isobutanol 6.29
1,4-dioxane 4.15
methyl acetate 5.6
THF 94.45
2-butanone 16.07
n-pentanol 7.03
sec-butanol 13.65
n-hexane 0.01
ethylene glycol 11.37
NMP 69.09
cyclohexane 0.01
DMSO 814.7
n-butyl acetate 5.83
n-octanol 2.14
chloroform 0.0
n-propyl acetate 5.69
acetic acid 5.19
dichloromethane 0.0
cyclohexanone 12.04
propylene glycol 20.97
isopropyl acetate 5.32
DMAc 87.43
2-ethoxyethanol 57.21
isopentanol 9.91
n-heptane 0.03
ethyl formate 4.43
1,2-dichloroethane 0.04
n-hexanol 4.48
2-methoxyethanol 182.91
isobutyl acetate 1.37
tetrachloromethane 0.0
n-pentyl acetate 3.18
transcutol 49.1
n-heptanol 2.65
ethylbenzene 0.1
MIBK 5.89
2-propoxyethanol 66.74
tert-butanol 11.09
MTBE 1.94
2-butoxyethanol 18.73
propionic acid 7.25
o-xylene 0.11
formic acid 7.29
diethyl ether 1.91
m-xylene 0.12
p-xylene 0.1
chlorobenzene 0.02
dimethyl carbonate 3.69
n-octane 0.02
formamide 21.24
cyclopentanone 41.58
2-pentanone 14.65
anisole 0.84
cyclopentyl methyl ether 7.46
gamma-butyrolactone 46.01
1-methoxy-2-propanol 152.04
pyridine 2.31
3-pentanone 4.56
furfural 15.07
n-dodecane 0.03
diethylene glycol 68.11
diisopropyl ether 0.35
tert-amyl alcohol 10.9
acetylacetone 13.32
n-hexadecane 0.03
acetophenone 2.19
methyl propionate 13.67
isopentyl acetate 4.24
trichloroethylene 0.05
n-nonanol 2.44
cyclohexanol 4.82
benzyl alcohol 2.26
2-ethylhexanol 2.18
isooctanol 2.04
dipropyl ether 2.95
1,2-dichlorobenzene 0.02
ethyl lactate 10.65
propylene carbonate 7.04
n-methylformamide 34.5
2-pentanol 7.74
n-pentane 0.01
1-propoxy-2-propanol 43.79
1-methoxy-2-propyl acetate 18.84
2-(2-methoxypropoxy) propanol 17.63
mesitylene 0.07
ε-caprolactone 15.64
p-cymene 0.22
epichlorohydrin 21.6
1,1,1-trichloroethane 0.01
2-aminoethanol 24.22
morpholine-4-carbaldehyde 50.51
sulfolane 121.98
2,2,4-trimethylpentane 0.02
2-methyltetrahydrofuran 17.32
n-hexyl acetate 3.98
isooctane 0.01
2-(2-butoxyethoxy)ethanol 27.52
sec-butyl acetate 2.98
tert-butyl acetate 6.13
decalin 0.01
glycerin 59.87
diglyme 37.34
acrylic acid 5.63
isopropyl myristate 1.67
n-butyric acid 13.9
acetyl acetate 1.41
di(2-ethylhexyl) phthalate 1.65
ethyl propionate 6.12
nitromethane 21.35
1,2-diethoxyethane 6.2
benzonitrile 0.84
trioctyl phosphate 1.93
1-bromopropane 0.08
gamma-valerolactone 77.05
n-decanol 1.82
triethyl phosphate 2.07
4-methyl-2-pentanol 3.09
propionitrile 3.21
vinylene carbonate 2.74
1,1,2-trichlorotrifluoroethane 17.06
DMS 2.77
cumene 0.09
2-octanol 1.66
2-hexanone 7.42
octyl acetate 2.42
limonene 0.33
1,2-dimethoxyethane 44.46
ethyl orthosilicate 1.74
tributyl phosphate 2.1
diacetone alcohol 40.14
N,N-dimethylaniline 0.83
acrylonitrile 5.14
aniline 0.76
1,3-propanediol 59.57
bromobenzene 0.01
dibromomethane 0.0
1,1,2,2-tetrachloroethane 0.09
2-methyl-cyclohexyl acetate 2.44
tetrabutyl urea 4.27
diisobutyl methanol 1.66
2-phenylethanol 2.78
styrene 0.06
dioctyl adipate 2.91
dimethyl sulfate 10.87
ethyl butyrate 5.13
methyl lactate 30.82
butyl lactate 8.39
diethyl carbonate 1.92
propanediol butyl ether 17.79
triethyl orthoformate 3.83
p-tert-butyltoluene 0.22
methyl 4-tert-butylbenzoate 4.41
morpholine 27.44
tert-butylamine 1.36
n-dodecanol 1.22
dimethoxymethane 39.4
ethylene carbonate 2.55
cyrene 18.93
2-ethoxyethyl acetate 6.07
2-ethylhexyl acetate 2.43
1,2,4-trichlorobenzene 0.06
4-methylpyridine 2.17
dibutyl ether 1.9
2,6-dimethyl-4-heptanol 1.66
DEF 24.28
dimethyl isosorbide 28.51
tetrachloroethylene 0.04
eugenol 6.16
triacetin 4.52
span 80 9.88
1,4-butanediol 10.2
1,1-dichloroethane 0.02
2-methyl-1-pentanol 4.82
methyl formate 10.71
2-methyl-1-butanol 9.19
n-decane 0.04
butyronitrile 3.76
3,7-dimethyl-1-octanol 2.04
1-chlorooctane 0.22
1-chlorotetradecane 0.1
n-nonane 0.03
undecane 0.03
tert-butylcyclohexane 0.01
cyclooctane 0.01
cyclopentanol 10.67
tetrahydropyran 3.82
tert-amyl methyl ether 3.38
2,5,8-trioxanonane 28.41
1-hexene 0.11
2-isopropoxyethanol 22.4
2,2,2-trifluoroethanol 1.64
methyl butyrate 9.76

Yes. Morin and its source plants may be referred to by several alternative names, including:

  1. morin
  2. 480-16-0
  3. Aurantica
  4. 2′,3,4′,5,7-Pentahydroxyflavone
  5. Calico Yellow
  6. Al-Morin
  7. Toxylon Pomiferum
  8. Bois d,Arc
  9. Bois d’arc
  10. C.I. Natural Yellow 8
  11. Osage Orange Crystals
  12. 2′-Hydroxypelargidenolon 1522
  13. 3,5,7,2′,4′-Pentahydroxyflavone
  14. 3,5,7,2′,4′-Pentahydroxyflavonol
  15. C.I. 75660
  16. 2-(2,4-dihydroxyphenyl)-3,5,7-trihydroxychromen-4-one
  17. Zlut prirodni 11
  18. 4H-1-Benzopyran-4-one, 2-(2,4-dihydroxyphenyl)-3,5,7-trihydroxy-
  19. 2′,4′,3,5,7-Pentahydroxyflavone
  20. 2′,4′,5,7-Tetrahydroxyflavan-3-ol
  21. C.I.Natural Yellow 8
  22. 2-(2,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-1-benzopyran-4-one
  23. 8NFQ3F76WR
  24. NSC-19801
  25. DTXSID1022398
  26. CHEBI:75092
  27. RefChem:819400
  28. DTXCID702398
  29. 3,2′,4′,5,7-pentahydroxyflavone
  30. 207-542-9
  31. 684-856-6
  32. 2-(2,4-Dihydroxyphenyl)-3,5,7-trihydroxy-4H-chromen-4-one
  33. C.I. Natural Yellow 11
  34. NSC 19801
  35. Aluminum Ionophore I
  36. NSC19801
  37. MFCD00006826
  38. Flavone, 2′,3,4′,5,7-pentahydroxy-
  39. CHEMBL28626
  40. MLS000069618
  41. 3,5 7 2 4-Pentahydroxyflavone
  42. 2′,4′,5,7-Tetrahydroxyflavonol
  43. 4H-1-Benzopyran-4-one, 2-2-(2,4-dihydroxyphenyl)-3,5,7-trihydroxy-
  44. 2-(2,4-dihydroxyphenyl)-3,5,7-trihydroxy-chromen-4-one
  45. SMR000058259
  46. 2-[2,4-bis(oxidanyl)phenyl]-3,5,7-tris(oxidanyl)chromen-4-one
  47. Bois d’arc [French]
  48. Zlut prirodni 11 [Czech]
  49. MORIN, REAG
  50. SR-01000000157
  51. 2-(2,4-dihydroxyphenyl)-3,5,7-trihydroxy-chromone
  52. EINECS 207-542-9
  53. UNII-8NFQ3F76WR
  54. BRN 0327474
  55. 3,5,7-Trihydroxy-2-(2,4-dihydroxyphenyl)-4H-chromen-4-one
  56. Morin anhydrous
  57. moric acid
  58. AI3-38057
  59. CCRIS 8680
  60. Morin (Standard)
  61. Spectrum_001234
  62. regid855692
  63. Spectrum2_000715
  64. Spectrum3_001941
  65. Spectrum4_001924
  66. Spectrum5_000737
  67. MORIN [MI]
  68. C.I. Natural yellow 8;
  69. Lopac0_000776
  70. SCHEMBL19984
  71. BSPBio_003541
  72. GTPL411
  73. KBioGR_002268
  74. KBioSS_001714
  75. 5-18-05-00492 (Beilstein Handbook Reference)
  76. MLS006012034
  77. BIDD:ER0115
  78. DivK1c_000958
  79. SPECTRUM1502259
  80. SPBio_000929
  81. MEGxp0_001864
  82. Morin, p.a., 97.0%
  83. orb1304960
  84. orb3140581
  85. 2′,3,5,7-Pentahydroxyflavone
  86. SCHEMBL29435805
  87. SCHEMBL29929115
  88. ACon1_000260
  89. BDBM26658
  90. BDBM34231
  91. cid_5281670
  92. HMS502P20
  93. HY-N0621R
  94. KBio1_000958
  95. KBio2_001714
  96. KBio2_004282
  97. KBio2_006850
  98. KBio3_002824
  99. WLZ4645
  100. 2′,4′,5,7-Pentahydroxyflavone
  101. 3,7,2′,4′-Pentahydroxyflavone
  102. NINDS_000958
  103. 2′,5,7-Tetrahydroxyflavan-3-ol
  104. GLXC-06986
  105. HMS1921P12
  106. HMS3262K14
  107. HMS5086B17
  108. Flavone,3,4′,5,7-pentahydroxy-
  109. HY-N0621
  110. Tox21_500776
  111. CCG-39036
  112. LMPK12112517
  113. s9110
  114. SBB008853
  115. STL559049
  116. 2′,3,4′,5,7-pentahydroxy flavone
  117. 2′,3,4′,5,7-Pentahydroxy-Flavone
  118. AKOS001582671
  119. EBC-431051
  120. LP00776
  121. SDCCGMLS-0003296.P003
  122. SDCCGSBI-0050754.P003
  123. 2′,4′,5, 7-Tetrahydroxyflavan-3-ol
  124. IDI1_000958
  125. SMP1_000199
  126. NCGC00015672-01
  127. NCGC00015672-02
  128. NCGC00015672-03
  129. NCGC00015672-04
  130. NCGC00015672-05
  131. NCGC00015672-06
  132. NCGC00015672-07
  133. NCGC00015672-08
  134. NCGC00015672-09
  135. NCGC00015672-10
  136. NCGC00015672-11
  137. NCGC00015672-12
  138. NCGC00015672-13
  139. NCGC00015672-14
  140. NCGC00015672-16
  141. NCGC00015672-24
  142. NCGC00015672-25
  143. NCGC00022214-03
  144. NCGC00022214-04
  145. NCGC00022214-05
  146. NCGC00022214-06
  147. NCGC00022214-07
  148. NCGC00178000-01
  149. NCGC00178000-02
  150. NCGC00261461-01
  151. AC-34723
  152. BS-32477
  153. FM145255
  154. NCI60_001647
  155. DB-051497
  156. CS-0009616
  157. EU-0100776
  158. NS00015830
  159. P0041
  160. ST50308676
  161. M 4008
  162. EN300-7400825
  163. AK-693/40760142
  164. F239134
  165. Q418224
  166. 91A9D69E-FAB0-45CD-90E5-DEEFBADE86C1
  167. SR-01000000157-2
  168. SR-01000000157-6
  169. SR-01000000157-7
  170. BRD-K11590034-001-01-0
  171. BRD-K11590034-002-02-6
  172. BRD-K11590034-002-03-4
  173. 2′,3,4′,5,7-Pentahydroxyflavone, C.I. No. 75660
  174. Aluminum Ionophore I, Selectophore(TM), function tested
  175. 2-(2,4-dihydroxyphenyl)-3,5,7-trihydroxy-1-benzopyran-4-one
  176. 2′,4′,5,7-Tetrahydroxyflavonol; 2′-Hydroxypelargidenolon 1522;
  177. 2-(2,4-Dihydroxyphenyl)-3,5,7-trihydroxy-4H-chromen-4-one #
  178. 2-(2,4-Dihydroxyphenyl)-3,5,7-trihydroxy-4H-1-benzopyran-4-one, 9CI
  179. Old Fustic
  180. M 3735